# HUMAN TUMOR HOST RELATIONSHIPS IN VIVO

> **NIH NIH R01** · STANFORD UNIVERSITY · 1988 · $131,136

## Abstract

Despite major advances in the diagnosis and treatment of human
lymphomas, there remains considerable heterogeneity in clinical
behavior within traditional subgroups.  Application of newer
diagnostic modalities, including monoclonal antibodies and nucleic
acid probes, has not yet had a major impact on improving the
predictability of clinical behavior for many patients.  This project
will address three major aspects of the tumor host reaction in
vivo: (1) expression of target cell recognition structures LFA-1,
HLA-Class I, and HLA-Class II in lymphoma subgroups, (2)
enumeration of effector cell subtypes in lymphoma subgroups, (3)
level of expression of proliferation and "activation" associated
markers in subtypes of lymphoma.  Ongoing studies will rely
heavily on frozen section immunohistochemical staining combined
with estimation and quantitation methods for enumerating types
and numbers of immune cells.  Automated cell analysis systems
will be employed as they are developed.  A better understanding
of important tumor and host features may aid in the selection of
current treatment modalities, provide the rational for delay
treatment and may prove useful in devising experimental
treatment strategies.  Long term goals are to devise a more
reproducible, clinically predictive classification of lymphomas.
Such an in vivo evaluation of tumor host relationship should
provide valuable insights in lymphoma immunobiology.

## Key facts

- **NIH application ID:** 3171075
- **Project number:** 2R01CA033119-04A1
- **Recipient organization:** STANFORD UNIVERSITY
- **SAM.gov UEI:** HJD6G4D6TJY5
- **Principal Investigator:** ROGER A WARNKE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $131,136
- **Award type:** 2
- **Project period:** 1984-01-01 → 1990-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3171075

## Citation

> US National Institutes of Health, RePORTER application 3171075, HUMAN TUMOR HOST RELATIONSHIPS IN VIVO (2R01CA033119-04A1). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3171075. Licensed CC0.

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