# EXPRESSION OF HBV GENES AND HEPATOMA

> **NIH NIH R01** · UNIVERSITY OF COLORADO DENVER · 1991 · $176,852

## Abstract

Infection with hepatitis B in man is a major health problem of worldwide
concern. Its involvement in chronic liver disease and primary
hepatocellular caricinoma among carriers signifies the importance of
investigating the basic biology of this virus, which is crucial to the
development of safe, economic and practical procedures of control of HBV
infection. The general aim of the proposed studies is to continue to
understand the genetic structure of the HBV genome, investigate the
mechanism of viral pathogenesis and carefully examine the oncogenic role
of HBV in hepatocarcinogenesis.

The major emphasis will be placed on the development and extensive use of
expression vectors programmed to synthesize HBV genes in mammalian cells.
Approaches will be designed to determine DNA sequences with regulatory
functions, enhancer functions and functions whose expression leads to the
malignant transformation of cells in culture.

## Key facts

- **NIH application ID:** 3171092
- **Project number:** 2R01CA033135-07A2
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **SAM.gov UEI:** MW8JHK6ZYEX8
- **Principal Investigator:** ALEEM SIDDIQUI
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $176,852
- **Award type:** 2
- **Project period:** 1982-07-01 → 1995-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3171092

## Citation

> US National Institutes of Health, RePORTER application 3171092, EXPRESSION OF HBV GENES AND HEPATOMA (2R01CA033135-07A2). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3171092. Licensed CC0.

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