# MULTIDIMENSIONAL SLIT SCAN DETECTION OF BLADDER CANCER

> **NIH NIH R01** · UNIVERSITY OF ROCHESTER · 1987 · $264,533

## Abstract

The goal of this project is to apply multidimensional slit-scan technology
to the examination and analysis of exfoliated bladder epithelium for the
detection, diagnosis, and monitoring of cancer of the urinary bladder and
its precursors.

Static cell slit-scan cytofluorometer studies have been performed on
bladder irrigation specimens representing a variety of cellular disorders
of the bladder mucosa associated with and including invasive transitional
cell carcinoma.  Included in this database are normal specimens, specimens
from low-grade papillary transitional cell carcinoma, and high-grade
invasive cancer.  Static cell analyses have suggested that correct
identification of abnormal specimens from the bladder can be achieved
utilizing the slit-scan technique with minimal modification of existing
software.  Abnormal cells derived from transitional cell carcinoma are
delineated from normal cells by the feature nuclear fluorescence.  Atypical
cells of transitional type fall in an area between the normal and clearly
abnormal cell populations.  Other studies are directed at identifying
potential causes of false alarms and developing a protocol for staining and
fixing bladder irrigation specimens.  One hundred eleven specimens have
been analyzed in a preliminary clinical study on a multidimensional
slit-scan flow system.  These included 84 specimens representing a spectrum
of abnormality present in the human bladder.  The system false negative
rate was 4.7% and the false positive rate was 17%.  Current efforts are
directed toward expanding this preliminary flow database and exploring the
utility of other features available from multidimensional slit-scan
analysis.  (3)

## Key facts

- **NIH application ID:** 3171112
- **Project number:** 5R01CA033148-06
- **Recipient organization:** UNIVERSITY OF ROCHESTER
- **SAM.gov UEI:** F27KDXZMF9Y8
- **Principal Investigator:** LEON L WHEELESS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $264,533
- **Award type:** 5
- **Project period:** 1982-08-01 → 1988-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3171112

## Citation

> US National Institutes of Health, RePORTER application 3171112, MULTIDIMENSIONAL SLIT SCAN DETECTION OF BLADDER CANCER (5R01CA033148-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3171112. Licensed CC0.

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