# REGULATION OF MYELOID PROGENITOR CELL DIFFERENTIATION

> **NIH NIH R01** · SLOAN-KETTERING INST CAN RESEARCH · 1987 · $220,390

## Abstract

The object of this project is to analyze in depth the expression of
regulatory phenotypes of normal and leukemic human progenitor cells, to
correlate regulatory phenotype with the growth behavior of progenitor cells
in vitro, and to define mechanisms for altering abnormal phenotypes in
order to modify abnormal cell differentiation.  A unique limited suspension
culture system with prostaglandin E1 (PGE1) will be used to modulate
CFU-GM HLA-DR expression and investigate its implication in the control of
CFU-GFM proliferation.  A multifaceted in-depth study of specific
modulation of antigenic expression and regulatory responsiveness in a
strategy designed to restore a normal pattern of proliferation and
differentiation offers a mechanism for control of leukemic cell
proliferation and suggests an alternative approach to therapy.  Evidence
indicates that the disordered regulation observed in patients with CML can
be restored by modulation of CFU-GM Ia-antigen following exposure to PGE.
Analysis of normal, accessory cell function indicates a role for T
lymphocytes in the control of CFU-GM cell cycle and Ia antigen expression.
The mechanism(s) of action of T cells in normal and abnormal human
myelopoiesis will be investigated.  (MB)

## Key facts

- **NIH application ID:** 3171182
- **Project number:** 5R01CA033225-06
- **Recipient organization:** SLOAN-KETTERING INST CAN RESEARCH
- **SAM.gov UEI:** KUKXRCZ6NZC2
- **Principal Investigator:** Louis M Pelus
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $220,390
- **Award type:** 5
- **Project period:** 1985-09-01 → 1988-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3171182

## Citation

> US National Institutes of Health, RePORTER application 3171182, REGULATION OF MYELOID PROGENITOR CELL DIFFERENTIATION (5R01CA033225-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3171182. Licensed CC0.

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