# NOVEL ANTINEOPLASTIC AGENTS FROM HIGHER PLANTS

> **NIH NIH R01** · OHIO STATE UNIVERSITY · 1991 · $183,646

## Abstract

This research project is designed to carry out bioassay-directed
isolation, structural elucidation, and chemical studies of novel
antineoplastic agents from higher plants which have confirmed
activity in a panel of human tumors in cell culture.  The cell
lines which are in place (HT-29, A549, MCF-7, RPMI-7951 and TE671)
have been chosen based on consideration of refractory disease-type
and overlap with the panel of human tumor cell lines being
established by the National Cancer Institute (NCI).

Plant materials are obtained through botanical contacts world-wide
and from NCI.  A large number of plant extracts are on hand with
confirmed activity in these systems and/or 9PS.  Bioactivity-
directed fractionation is underway on Annona species, Canaga
oderata, Anomodon species and other mosses including Claopodium
crispifolium and polytrichum ohioensis.  Structural work and
chemical studies are underway on crystalline actives from
psorospermum febrifugum, Annona densicoma, A. reticulata,
polytrichum ohioensis and others, Compounds with selective activity
for the human tumor cells have been discovered and are under study.
Selected novel actives will be submitted to the NCI for further
evaluation in the NCI human tumor panel and animal models.  This
research will provide additional novel antineoplastic agents which
have clinical potential.  Compounds discovered will also serve as
structural prototypes for analog synthesis and as biochemical
probes which may aid in the elucidation of novel mechanisms of
growth control and novel therapeutic targets.

## Key facts

- **NIH application ID:** 3171256
- **Project number:** 5R01CA033326-09
- **Recipient organization:** OHIO STATE UNIVERSITY
- **SAM.gov UEI:** DLWBSLWAJWR1
- **Principal Investigator:** JOHN M CASSADY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $183,646
- **Award type:** 5
- **Project period:** 1982-09-30 → 1992-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3171256

## Citation

> US National Institutes of Health, RePORTER application 3171256, NOVEL ANTINEOPLASTIC AGENTS FROM HIGHER PLANTS (5R01CA033326-09). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3171256. Licensed CC0.

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