# EXPERIMENTAL URINARY BLADDER CARCINOGENESIS

> **NIH NIH R01** · NORTHWESTERN UNIVERSITY · 1988 · $137,766

## Abstract

Urinary bladder cancer encompasses a spectrum of neoplasms ranging from
low-grade papillary tumors to high-grade aggressive tumors.  The majority
of tumors are of the former type and characteristically recur following
surgical resection.

Our overall objective is to investigate both mechanisms of urinary bladder
carcinogenesis and methods for prevention of recurrence of neoplasms.

The immediate objective is to obtain evidence supporting our working
hypothesis which states that "the progression to cancer of initiated
bladder epithelial cells is aided by factors which stimulate cell
replication."  The factors include the specific urinary components capable
of inducing ornithine decarboxylase (ODC), and chemical and physical trauma
stimulating continued or repeated regenerative hyperplasia.

The specific aims to test the hypothesis are:

1) to clarify the mechanism(s) of the inhibitory actions demonstrated by an
irreversible inhibitor of ODC, Alpha-difluoromethylornithine, on
carcinogenesis in the heterotopically transplanted urinary bladder system,

2) to determine whether the carcinogenesis in the natural bladder system
can be similarly inhibited by chronic oral administration of DFMO, and

3) to determine whether the diffuse papillomatosis of the rat urinary
bladder which develops in association with bladder calculi without known
prior carcinogen exposure, is reversible following removal of the physical
stimulus (calculus).

These studies will be conducted using the heterotopically transplanted
urinary bladder system developed in our laboratory, and natural bladders.

## Key facts

- **NIH application ID:** 3171367
- **Project number:** 5R01CA033511-06
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **SAM.gov UEI:** KG76WYENL5K1
- **Principal Investigator:** RYOICHI OYASU
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $137,766
- **Award type:** 5
- **Project period:** 1982-09-01 → 1990-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3171367

## Citation

> US National Institutes of Health, RePORTER application 3171367, EXPERIMENTAL URINARY BLADDER CARCINOGENESIS (5R01CA033511-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3171367. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*