# CANCER EPIDEMIOLOGY OF THE MIGRANT JAPANESE IN HAWAII

> **NIH NIH R01** · KUAKINI MEDICAL CENTER · 1987 · $434,786

## Abstract

Eight thousand and six men of Japanese ancestry, born from 1900-1919 and
residing on the island of Oahu, were examined in an epidemiologic-based
study from 1965 to 1968.  A wealth of dietary, social, personal, and
laboratory information was obtained from the men.  Since the examination,
we have identified in our prospective study 96 incident cases of stomach
cancer, 90 of the colon, 85 of the lung, 72 of the prostate, 57 of the
rectum, 31 of the urinary bladder, and 28 fo the pancreas for a total of
459 incident cancer cases.  Over the next five years we expect to identify
an additional 303 incident cases of these common cancers with our hospital
surveillance network.  With the past collection of sera samples and
extensive epidemiologic data, especially in the area of diet and nutrition,
we propose to do the following:  1) determine if there is an association of
dietary fat, dietary fiber, alcolol intake or serum vitamin A levels with
large bowel cancer; 2) determine if dietary nitrites, salt, vegetables,
fruits or specific vitamins are related to stomach cancer; 3) identify
dietary, hormonal and other factors associated with clinical prostate
cancer; 4) investigate the association of dietary and serum vitamin A, and
alcohol with lung cancer; 5) identify risk factors for pancreatic and
urinary bladder cancer; 6) determine the association of serum vitamins A
and E with common epithelial cancers.  We also propose to do a study in
which colonoscopy subjects with and without adenomatous polyps, a precursor
lesion of colon cancer, will be compared in their consumption of over 100
different dietary items.  A similar study will be done to identify dietary
factors related to intestinal metaplasia (a precursor lesion of stomach
cancer) among gastroscopy subjects.  This proposal is focused towards a
better understanding of the risk factors associated with common cancers,
and thereby would contribute to the ultimate development of practical
interventions which could reduce the incidence of these diseases.  The
disciplines of epidemiology, pathology, biostatistics and nutrition are
integrated into this project.

## Key facts

- **NIH application ID:** 3171456
- **Project number:** 5R01CA033644-05
- **Recipient organization:** KUAKINI MEDICAL CENTER
- **SAM.gov UEI:** M9GKSQB7UJ65
- **Principal Investigator:** ABRAHAM M NOMURA
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $434,786
- **Award type:** 5
- **Project period:** 1983-09-15 → 1988-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3171456

## Citation

> US National Institutes of Health, RePORTER application 3171456, CANCER EPIDEMIOLOGY OF THE MIGRANT JAPANESE IN HAWAII (5R01CA033644-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3171456. Licensed CC0.

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