# TISSUE LIGHT TRANSPORT & DOSAGE IN PHOTODYNAMIC

> **NIH NIH R01** · HENRY FORD HOSPITAL · 1987 · $124,647

## Abstract

This research deals with the photophysics of photodynamic
therapy (PDT) utilizing coherent and noncoherent light and it's
tissue transport to PDT cancer treatment sites.  Our objectives
are to quantitate the processes of scatter, reflection and
absorbance in tissue and learn how these principles may be
utilized.  We have begun to develop procedures for the estimation
and delivery of a uniform, efficient photon light dosage so that
tumor oblation may occur without damage to normal tissue.  We
have studied the red region and the visible band from both laser
and incoherent sources, coupling laser beams to fiberoptics for
instillation, and using beam expanders and incoherent sources for
external light delivery.  We have compiled transmittance and
spectral data on many mammalian tissues at PDT wavelengths,
and for the 400 to 1100 nm band have established penetration
depths across this region for several tissues.  We are extending
this research.  Study has been carried out in tissue, on simulators,
and with tissue phantoms.  A series of mammalian tissues is being
studied across species boundaries.  Species similarities and
variations have been established.  This cross-species investigation
continues and will include human specimens during the later
research phase.  The ultimate goal is establishment of a photon
dosage prediction system for all tissue, tumor types, for photon
energies, and sources.  We are developing a method of
experimentally determining space irradiance, describing the level
and extent of light diffusion through a three dimensional tissue
volume.  Our experimental results in three dimensions, to date,
show a basic exponential form.  This finding, which supports some
of the proposed theoretical models, developed by ourselves and
others, is the result of the first systematic series of
measurements in 3-D tissue volumes.  Additionally, work will be
carried out concurrently on a theoretical base for the prediction
of transport of light through tissue.  Applications of the diffision
and Kubelka-Monk equations are being made to interpret our
experimental data.  We shall expand our determinations of tissue
refraction for selected wavelengths, and of scattering and
absorption coefficients.  We have developed several computer
programs to aid in the experimental and theoretical work and they
are now in use.  Basic data generated by this study will be used to
develop a light dosage planning system for PDT clinical use.

## Key facts

- **NIH application ID:** 3171498
- **Project number:** 2R01CA033727-04
- **Recipient organization:** HENRY FORD HOSPITAL
- **Principal Investigator:** LUTHER E PREUSS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $124,647
- **Award type:** 2
- **Project period:** 1984-01-01 → 1991-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3171498

## Citation

> US National Institutes of Health, RePORTER application 3171498, TISSUE LIGHT TRANSPORT & DOSAGE IN PHOTODYNAMIC (2R01CA033727-04). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3171498. Licensed CC0.

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