# DYNAMIC PHANTOMS FOR ULTRASOUND HYPERTHERMIA

> **NIH NIH R01** · SRI INTERNATIONAL · 1988 · $246,583

## Abstract

In this continuing study SRI proposes to model, fabricate and validae
ultrasound tissue-equivalent phantoms of the pig kidney.  The thermal
response of these phantoms during and after hyperthermic exposure to
ultrasound will be compared with the results of modeling and of measuring
the thermal response of the kidney in the anesthetized pig when it is
heated by the same applicators.

SRI will develop numerical models based on the bioheat transfer equation
and its modified form that includes incomplete counter-current heat
exchange in artery-vein pairs.  The performance of a prototypical phantom
will be predicted by each model using the finite difference technique and
the known SAR pattern of an ultrasound applicator.  The parameters of the
models will be adjusted to approximate the measured response of the live
pig kidney to hyperthermia induced by the same applicator.  Conditions will
be sought under which the predicted performance of the prototypical phantom
differs in the two numerical models.  If these conditions are
physiologically significant, they will guide and constrain the design of
the physical phantoms.

In addition to providing data with which the performance of the phantoms
can be compared, the further objective of the animal experiments to be
performed at Stanford University is to quantify and evaluate the effects of
varying blood flow on the three-dimensional temperature distributions
induced by ultrasound in pig kidney.  This information will be useful and
necessary for the clinical application of ultrasound-induced localized
hyperthermia to treatment of tumors of soft tissues in general and kidney
tumors in particular.  Temporal and spatial temperature profiles will be
measured under conditions of normal and subnormal blood flow rates.
Temperature distributions will be correlated with local blood flow rates
and emitted ultrasonic power levels.

SRI proposes to continue to develop new tissue-equivalent materials capable
of simulating the ultrasonic energy absorptive and thermal transport of
kidney cortex and to devise means of perfusing tissue-equivalent materials
to simulate heat loss due to blood flow.  Dynamic phantoms will then be
fabricated and evaluated; temporal and spatial temperature profiles will be
recorded during heating, steady-state, and cooling phases with known
perfusate flow rates and temperatures and known ultrasonic power input.  A
microcomputer-based temperature monitoring system capable of monitoring 100
temperature sensors will be further refined to facilitate this study.
Temperature distributions will also be determined my means of a
thermographic camera.  The resulting models, phantoms and new knowledge
will provide means for evaluating the effectiveness of ultrasound
applicators, will facilitate validation of computer models of hyperthermia,
and thus will aid in treatment planning.

## Key facts

- **NIH application ID:** 3171540
- **Project number:** 5R01CA033749-05
- **Recipient organization:** SRI INTERNATIONAL
- **SAM.gov UEI:** SRG2J1WS9X63
- **Principal Investigator:** PETER D EDMONDS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $246,583
- **Award type:** 5
- **Project period:** 1983-07-01 → 1990-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3171540

## Citation

> US National Institutes of Health, RePORTER application 3171540, DYNAMIC PHANTOMS FOR ULTRASOUND HYPERTHERMIA (5R01CA033749-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3171540. Licensed CC0.

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