# HEPATIC TUMOR MICROCIRCULATION AND MICROSPHERE THERAPY

> **NIH NIH R01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 1992 · $221,081

## Abstract

DESCRIPTION:  (Adapted from applicant's abstract) The objective of this
application is to develop new, unique therapies to more completely and
rapidly control bulk cancer within the liver.  One element of the
applicant's approach is the use of hepatic arterial administration of
Yttrium 90 glass microspheres (Y90 MS) to selectively irradiate
hypervascular regions of tumors.  His current phase I clinical study has
found no dose-related toxicity at 12,500 rads of Y90 MS.  This
investigation will be continued to define the maximum tolerated dose
(anticipated from his animal studies at greater than or equal to 20,000
rads).  Based upon his studies demonstrating improvement in tumor to normal
liver deposition of tracer microspheres with short HA infusion of
epinephrine, a phase I-II study utilizing epinephrine with Y90 MS
subsequently will be developed using a balloon occlusion catheter to
prevent extrahepatic reflux of Y90 MS.  The second element of the
applicant's approach is the addition of HA 5-bromo-2'-deoxyuridine (BUDR)
as a radiosensitizer, a treatment that is pharmacologically rational as
substantiated by his animal and clinical studies.  In vivo antitumor
effects resulting from BUDR-induced radiosensitization with Y9O MS will be
explored in rabbits hearing the VX2 tumor (intrahepatically implanted).
Toxicology studies will be performed in dogs at relevant dose/schedules of
HA BUDR and Y90 MS (as was previously done for Y90 MS alone).  The results
of the clinical studies of Y90 MS alone and of the animal studies combining
Y90 MS with BUDR will be utilized during the 04-05 grant years to develop a
phase I study of the combination and to gain approval of same from the NCI
and FDA.

## Key facts

- **NIH application ID:** 3171610
- **Project number:** 5R01CA033825-09
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **SAM.gov UEI:** GNJ7BBP73WE9
- **Principal Investigator:** WILLIAM D ENSMINGER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $221,081
- **Award type:** 5
- **Project period:** 1983-05-01 → 1995-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3171610

## Citation

> US National Institutes of Health, RePORTER application 3171610, HEPATIC TUMOR MICROCIRCULATION AND MICROSPHERE THERAPY (5R01CA033825-09). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3171610. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*