# METABOLISM OF PANCREATIC CARCINOGENS--SPECIES DIFFERENCE

> **NIH NIH R01** · NORTHWESTERN UNIVERSITY · 1989 · $139,837

## Abstract

The major thrust of this reseach is to continue the systematic
investigation of intraspecies differences in the metabolism of certain
Beta-oxidized notrosamine carcinogens, such as
N-nitroso-2,6-dimethylomorpholine (NNDM), N-nitrosobis(2-oxopropyl)-amine
(BOP), and N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP) which
exhibit marked differences in carcinogenic potency and organotropy between
the rat and hamster.  These involve in vivo and in vitro studies in Syrian
golden hamsters and Fischer 344 rats treated with NNDM, BOP and HPOP, and
include 1) their in vivo metabolism including formation of the putative
proximate carcinogens MOP and MHP; 2) the pharmaco-kinetics of their uptake
and excretion; 3) formation and identification of major adducts in liver
and pancreas; 4) metabolism in primary pancreatic acinar cell and
hepatocyte cultures; 5) their in vitro metabolism by subcellualr fractions;
6) their activation by isolated hepatocytes to mutagenic metabolites as
assayed by the V79 cell system and the capacity of ancinar and liver cells
to repair DNA damage as measured by unscheduled DNA repair; 7) the uptake
of BOP and HPOP by isolated pancreatic ancinar cells and their binding to
DNA and RNA; and 8) a test of the hypothesis that sulfate ester formation
of HPOP may be important in its activation by determining whether
modulation of the sulfate pool significantly alters the yield of tumor
induced by HPOP in hamsters.

## Key facts

- **NIH application ID:** 3171784
- **Project number:** 5R01CA034051-07
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **SAM.gov UEI:** KG76WYENL5K1
- **Principal Investigator:** DANTE G. SCARPELLI
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $139,837
- **Award type:** 5
- **Project period:** 1983-02-01 → 1991-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3171784

## Citation

> US National Institutes of Health, RePORTER application 3171784, METABOLISM OF PANCREATIC CARCINOGENS--SPECIES DIFFERENCE (5R01CA034051-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3171784. Licensed CC0.

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