# SV40 DELETION MUTANTS--ONCOGENIC PROTEINS

> **NIH NIH R01** · UNIVERSITY OF COLORADO · 1989 · $153,340

## Abstract

The long-range goal of our research is to understand the process by which
simian virus 40 acts to transform cells in culture and to cause tumors in
animals.  We propose to examine the roles that SV40-encoded proteins play
in transformation and oncogenicity.  By understanding the mechanism of SV40
oncogenesis, we hope to move closer to an understanding of human cancer.

Our specific aims are to use an SV40 early region deletion mutant that we
have isolated to discover the SV40 functions that are involved in cellular
transformation and oncogenesis.  The mutant, F8dl, lacks over 60% of the
coding sequences for the SV40 large tumor antigen and yet this mutant still
can transform and cause tumors.  We propose to answer the following
questions:  1) Does the F8dl-encoded T antigen bind to specific sites on
cellular DNA?  2) Does the F8dl-encoded T antigen bind to specific
sequences on cellular chromatin?  3) Are interactions of T antigen within
cellular nuclei important for transformation and if so, how does T antigen
act within the nucleus to transform?

## Key facts

- **NIH application ID:** 3171813
- **Project number:** 5R01CA034072-06
- **Recipient organization:** UNIVERSITY OF COLORADO
- **SAM.gov UEI:** SPVKK1RC2MZ3
- **Principal Investigator:** LAUREN M SOMPAYRAC
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $153,340
- **Award type:** 5
- **Project period:** 1983-04-01 → 1992-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3171813

## Citation

> US National Institutes of Health, RePORTER application 3171813, SV40 DELETION MUTANTS--ONCOGENIC PROTEINS (5R01CA034072-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3171813. Licensed CC0.

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