# VIRAL MALIGNANT LYMPHOMAGENESIS

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 1990 · $277,528

## Abstract

Lymphomagenesis is a mulitstep process in which the lymphoma
cells become increasingly tumorigenic with time.  In the initial
phases of the disease, growth factor-dependent cells dominate;
During the progression phases chromosome and oncogene
rearrangements prevail.  Leukemias possessing chromsomes or
oncogene rearrangements have a poor prognosis compared to
those lacking genetically-fixed rearrangements.  Thus, it is of
upmost importance to study the initial, growth-factor dependent
phases of the disease so as to facilitate the design of rational
approaches of intervention before gene rearrangementts occur.

T leukemia/lymphomas of mice that are induced by radiation (an
etiologic agent) initially comprise growth factor-dependent,
autocrine cells.  The nature of the growth factor (coined
Lymphoma Growth Factor, LGF) and its cell surface receptor
(LGF-R) will be studied by molecular cloning of genes encoding
them.  Molecular clones encoding the LGF and LGF-R will be
studied on the nucleic acid and protein level.  Antibodies specific
for the LGF and LGF-R will be prepared.  The site(s) at which
LGF/LGF-R-positive cells first evolve in treated mice, as well as
the characteristics of such cells will be studied.  The existance
and phenotypes of LGF/LGF-R-positive cells in non-treated mice
will also be studied.

Childhood Acute Lymphoblastic Leukemia of T cells (T-ALL) also
appears to involve an LGF-dependent phase in which a growth
factor similar to the murine LGF is implicated.  Thus the study of
the early, growth factor-dependent phase of murine lymphoma
should further our understanding of childhood T-ALL as well.

## Key facts

- **NIH application ID:** 3171920
- **Project number:** 5R01CA034151-09
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **SAM.gov UEI:** UYTTZT6G9DT1
- **Principal Investigator:** Martin nmi Haas
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $277,528
- **Award type:** 5
- **Project period:** 1982-05-01 → 1992-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3171920

## Citation

> US National Institutes of Health, RePORTER application 3171920, VIRAL MALIGNANT LYMPHOMAGENESIS (5R01CA034151-09). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3171920. Licensed CC0.

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