# DIETARY PROTEIN AND CHEMICAL CARCINOGENESIS

> **NIH NIH R01** · CORNELL UNIVERSITY · 1987 · $160,625

## Abstract

The decrease in aflatoxin B1 (AFB1) induced liver tumor incidence
associated with low dietary protein will be studied.  We will examine the
hypothesis which states that the lower tumor yield caused by the lower
intake of protein is primarily associated with events occuring during the
post-initiation phase.  The Fisher 344 male rat will be the animal model of
choice and the measurement of Gamma-glutamyl transpeptidase positive (GGT+)
foci of altered hepatocytes will be employed as the indicator of early
preneoplasia.

The specific aims are 1) to evaluate the kinetic relationship between AFB1
dose, dietary protein level and time of emergence of GGT+ foci, 2) to
compare the contribution of AFB1 dose with dietary protein level on the
emergence of GGT+ foci, 3) to develop a single AFB1 dose protocol to better
separate initiation and postinitiation events, 4) to evaluate possible
mechanisms concerned with cell proliferation, immune surveillance and tumor
cell aggressiveness, and 5) to test whether the same phenomena occur in a
full-term tumor study.

The significance of this research is supported by the suggestion that high
protein intake is a cancer risk factor, which is a suggestion based on
rather comprehensive animal and human data.  The development of a good
tumor model system to study this relationship is very much needed.

## Key facts

- **NIH application ID:** 3171961
- **Project number:** 5R01CA034205-04
- **Recipient organization:** CORNELL UNIVERSITY
- **SAM.gov UEI:** G56PUALJ3KT5
- **Principal Investigator:** COLIN T CAMPBELL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $160,625
- **Award type:** 5
- **Project period:** 1984-03-01 → 1989-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3171961

## Citation

> US National Institutes of Health, RePORTER application 3171961, DIETARY PROTEIN AND CHEMICAL CARCINOGENESIS (5R01CA034205-04). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3171961. Licensed CC0.

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