# SYNTHESIS OF MACROCYCLIC ANTITUMOR ANIBIOTICS

> **NIH NIH R01** · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 1988 · $100,475

## Abstract

Synthetic routes to prototype macrocyclic, bicyclic, and spirocyclic units
present in the novel macrocyclic tetronic acid antitumor antibiotic,
kijanimicin, will be examined.  The aglycone kijanolide is the initial
target of this project.  The synthetic methods developed here will have
general utility in the synthesis of other complex carbocyclic substances.
The individual units and their combinations represent novel structures with
potential biological activity in the antitumor and antibiotic areas.
Kijanimicin shows activity against anaerobic bacteria and acts as an
antimalarial in mice.  Tetrocarin-A, a close analog of kijanimicin,
suppresses RNA synthesis in B subtilis and inhibits growth of experimental
sarcoma 180 and leukemia P338 tumors in mice.

## Key facts

- **NIH application ID:** 3171985
- **Project number:** 5R01CA034247-06
- **Recipient organization:** UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
- **SAM.gov UEI:** J22LNTMEDP73
- **Principal Investigator:** JAMES A MARSHALL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $100,475
- **Award type:** 5
- **Project period:** 1983-05-15 → 1989-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3171985

## Citation

> US National Institutes of Health, RePORTER application 3171985, SYNTHESIS OF MACROCYCLIC ANTITUMOR ANIBIOTICS (5R01CA034247-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3171985. Licensed CC0.

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