# SYNTHESIS OF MACROCYCLIC ANTITUMOR ANTIBIOTICS

> **NIH NIH R01** · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 1990 · $122,927

## Abstract

Synthetic routes to prototype macrocyclic, bicyclic, and spirocyclic units
present in the novel macrocyclic tetronic acid antitumor antibiotic,
kijanimicin, will be examined.  The aglycone kijanolide is the initial
target of this project.  Particular attention will be accorded to the
tetronic acid substructure and the macrocyclic ring of the aglycon.  The
synthetic methods developed here will have general utility in the synthesis
of other complex carbocyclic substances, including chlorothricolide and
tetrocarin-A.  The individual units and their combinations represent novel
structures with potential biological activity in the antitumor and
antibiotic areas.  Kijanimicin shows activity against anaerobic bacteria
and acts as an antimalarial in mice.  Tetrocarin-A, a close analog of
kijanimicin, suppresses RNA synthesis in B. subtilis and inhibits growth of
experimental sarcoma 180 and leukemia P338 tumors in mice.

## Key facts

- **NIH application ID:** 3171986
- **Project number:** 5R01CA034247-08
- **Recipient organization:** UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
- **SAM.gov UEI:** J22LNTMEDP73
- **Principal Investigator:** JAMES A MARSHALL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $122,927
- **Award type:** 5
- **Project period:** 1983-05-15 → 1992-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3171986

## Citation

> US National Institutes of Health, RePORTER application 3171986, SYNTHESIS OF MACROCYCLIC ANTITUMOR ANTIBIOTICS (5R01CA034247-08). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3171986. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*