# BIOCHEMICAL MECHANISMS OF CELLULAR INVASION

> **NIH NIH R01** · NEW YORK UNIVERSITY · 1989 · $190,515

## Abstract

The aim of this application is to characterize specific aspects of
the biology of basic fibroblast growth factor (bFGF).  Basic FGF
interacts with heparan sulfate.  We have hypothesized that this
interaction forms a complex which is the biologically relevant form
of bFGF.  We hypothesize that when complexed to heparan sulfate,
bFGF is resistant to proteolytic and thermal denaturation, has
increased solubility and is an functionally active as fee bFGF.
Experiments will be performed to test these ideas.

Basic FGF binds to alpha 2 macroglobulin (alpha2M).  We shall
charactrize the nature of this complex.  The rate of formation, its
biological activities as well as its possible role in the
regulation of extracellular bFGF levels.

Finally, we whall test the role of bFGF in development.  Female
guinea pigs will be immunized, bread, and the offspring examined
for developmental abnormalities.  Passive immunization and
monoclonal antibodies may also used in addition to natural
immunization.

## Key facts

- **NIH application ID:** 3172000
- **Project number:** 2R01CA034282-06
- **Recipient organization:** NEW YORK UNIVERSITY
- **SAM.gov UEI:** NX9PXMKW5KW8
- **Principal Investigator:** DANIEL B RIFKIN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $190,515
- **Award type:** 2
- **Project period:** 1983-12-01 → 1993-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3172000

## Citation

> US National Institutes of Health, RePORTER application 3172000, BIOCHEMICAL MECHANISMS OF CELLULAR INVASION (2R01CA034282-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3172000. Licensed CC0.

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