# SYNTHESIS OF ACTINOBOLIN AND BACTOBOLIN

> **NIH NIH R01** · PENNSYLVANIA STATE UNIVERSITY, THE · 1987 · $81,544

## Abstract

The primary purpose of this research project is to complete efficient total
syntheses of the antitumor agents actinobolin and bactobolin from a common
bicyclic lactone intermediate.  This research should also make available
various unnatural analogs of these natural products for antitumor testing
by the National Cancer Institute.  In addition, the scope, utility and
applications of the intramolecular [4+2]-cycloaddition of N-acylimines with
alkenes will be explored.  This methodology will be applied to synthesis of
penem and carbapenem precursors, to the N-terminal Alpha-amino acid
components of the nikkomycins and neopolyoxins, and to polyoxamic acid, an
Alpha-amino acid component of the polyoxins.

## Key facts

- **NIH application ID:** 3172021
- **Project number:** 5R01CA034303-05
- **Recipient organization:** PENNSYLVANIA STATE UNIVERSITY, THE
- **SAM.gov UEI:** NPM2J7MSCF61
- **Principal Investigator:** STEVEN M. WEINREB
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $81,544
- **Award type:** 5
- **Project period:** 1983-06-01 → 1989-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3172021

## Citation

> US National Institutes of Health, RePORTER application 3172021, SYNTHESIS OF ACTINOBOLIN AND BACTOBOLIN (5R01CA034303-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3172021. Licensed CC0.

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