# ULTRASONIC PROPERTIES OF NORMAL AND PATHOLOGICAL TISSUES

> **NIH NIH R01** · SRI INTERNATIONAL · 1987 · $178,918

## Abstract

The purpose of the proposed research is to determine in detail the
dependence ultrasonic attenuation and sound speed on the pathological state
of breast tissue.  These data are required for an adequate assessment of
the potential of ultrasound transmission imaging and computed tomography in
breast cancer detection.  Freshly excised biopsy specimens will be
interrogated by finely focused ultrasound beam, and the transmitted
ultrasound will be detected by a phase-insensitive acoustoelectric
receiver, thereby eliminating artifacts due to phase cancellation that
might invalidate most attenuation measurements previously reported in the
literature.  The sample holder will be translated in a raster pattern to
obtain data at up to 256 locations in the specimen.  Data will be obtained
over the frequency range 2 to 9 MHz and stored for subsequent analysis.
Time-of-flight data will yield ultrasound speed at each location.

Detailed histological examination and reporting will enable ultrasonic data
to be correlated with the pathological state-this will be performed with
unprecedented accuracy of registration.  Results of this research will
permit an assessment of the potential of ultrasound transmission imaging
based on attenuation differences in the breast.  They will also be
pertinent to the interpretation of B-scan images and computed tomographic
images.

## Key facts

- **NIH application ID:** 3172092
- **Project number:** 2R01CA034398-04
- **Recipient organization:** SRI INTERNATIONAL
- **SAM.gov UEI:** SRG2J1WS9X63
- **Principal Investigator:** PETER D EDMONDS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $178,918
- **Award type:** 2
- **Project period:** 1984-03-01 → 1990-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3172092

## Citation

> US National Institutes of Health, RePORTER application 3172092, ULTRASONIC PROPERTIES OF NORMAL AND PATHOLOGICAL TISSUES (2R01CA034398-04). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3172092. Licensed CC0.

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