# OCCUPATIONAL AND ENVIRONMENTAL EXPOSURES IN THE ETIOLOGY

> **NIH NIH R01** · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 1987 · $290,908

## Abstract

The specific aim of the proposed research is to evaluate the joint
etiologic importance of occupational exposures, environmental
exposures and cigarette smoking among newly diagnosed cases of
adult male leukemia residing in six Texas Gulf Coast counties.
All new cases occurring between January 1982 and December
1986 will be included in the study.  Cases are identified through
a hospital-based ascertainment system and are confirmed for
study eligibility through a histopathlogic review.

The design is a population-based case-comparison study in which
exposure information is obtained through interview.  Two
comparison subjects are drawn from drivers' license tapes
provided to the investigators by the state of Texas, and
frequency matched to cases by age and race.

The study area contains one of the largest petrochemical
complexes in the world, and is well suited for the study of the
influence of occupations in these industries.

Analysis of the data will be by histologic types of leukemia
whenever numbers permit.  Interactions among the primary risk
factors will be examined by used of the logistic model.  Other
potentially important factors to be examined include familial
aggregation of leukemia and other cancer, prior exposure to
therapeutic radiation and chemotherapy, contact with sick pets,
and history of viral disease.

## Key facts

- **NIH application ID:** 3172141
- **Project number:** 2R01CA034448-04
- **Recipient organization:** UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- **SAM.gov UEI:** ZUFBNVZ587D4
- **Principal Investigator:** Patricia A Buffler
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $290,908
- **Award type:** 2
- **Project period:** 1984-03-01 → 1988-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3172141

## Citation

> US National Institutes of Health, RePORTER application 3172141, OCCUPATIONAL AND ENVIRONMENTAL EXPOSURES IN THE ETIOLOGY (2R01CA034448-04). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3172141. Licensed CC0.

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