# ETIOLOGY AND NATURAL HISTORY OF CERVICAL NEOPLASIA

> **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 1990 · $425,400

## Abstract

Cervical dysplasia and invasive carcinoma have been associated
with several sexually transmitted agents.  The particular agent(s)
involved has not yet been definitely identified although data
implicating human papilloma virus (HPV) at least in some cases,
have become compelling.  Data from our study, still in progress,
so far have identified HPV 16 or 18, chlamydia trachomatis, and
bacterial vaginosis as independently associated with cervical
dysplasia in a random sample of women attending a sexually
transmitted disease clinic; and show an interesting correlation of
past infectious monocleosis with cervical HPV 16/18 infection.
Other potential risk factors (eg, smoking, number of sexual
partners, HSV-2 infection) were not independent risk factors.
Among longitudinally followed cohorts of women, the risk of
dysplasia has ben highest among those with HPV infection,
especially those with HPV 16/18.  Certain patterns were
predictive of cervical HPV 16/18 infection.  We plan to continue
to monitor cervical cytology, densitometry, and analysis of the
state of HPV integration into host cell DNA, in the following
conditions:  cervical infection with HPV 6, 11, 16, 18, or other
types, with and without dysplasia; cervical dysplasia without
HPV infection; and for comparison, cohorts with first episode
genital herpes virus infection; cervical Chlamydia trachomatis
infection; and no cervical infection or dysplasia.  Data
concerning other risk factors, such as smoking, oral
contraceptive use, and family history will be collected in
conjunction with the above, in an effort to define the natural
history of cervical infection with HPV, and with of STDs of
interest, in relation to cervical dysplasia.

## Key facts

- **NIH application ID:** 3172229
- **Project number:** 5R01CA034493-07
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **SAM.gov UEI:** HD1WMN6945W6
- **Principal Investigator:** KING K. HOLMES
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $425,400
- **Award type:** 5
- **Project period:** 1983-12-01 → 1992-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3172229

## Citation

> US National Institutes of Health, RePORTER application 3172229, ETIOLOGY AND NATURAL HISTORY OF CERVICAL NEOPLASIA (5R01CA034493-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3172229. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*