# IMMUNOLOGICAL DEFECTS IN HUMAN IMMUNODEFICIENT STATES

> **NIH NIH R01** · OKLAHOMA MEDICAL RESEARCH FOUNDATION · 1987 · $204,140

## Abstract

Continued effort will be made to generate and characterize monoclonal
antibodies specific for later stages of B-cell differentiation.  Special
emphasis will be made in the identification of plasma cell-\and myeloma
cell-specific antigens.  Human T-T hybridoma technology will continue to be
developed and the feasibility of fusion under micromanipulation will be
tested.  T-cell factors generated by T-T hybridoma and specific for IgM and
IgG secretion, as well as factors for Ig isotype switching, will be
identified.  Emphasis also will be made to identify hidden serum Ig band in
CLL patients and to ascertain the feasibility to generate anti-idiotypic
monoclonal antibodies to the hidden serum Ig band.  T-cell factors which
would induce CLL cells to proliferate will be sought.  These studies will
yield information significant for our understanding of normal and
neoplastic B-cell proliferation and differentiation.  (LB)

## Key facts

- **NIH application ID:** 3172268
- **Project number:** 5R01CA034546-06
- **Recipient organization:** OKLAHOMA MEDICAL RESEARCH FOUNDATION
- **SAM.gov UEI:** NGCNCJ1X6XA4
- **Principal Investigator:** Shu Man Fu
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $204,140
- **Award type:** 5
- **Project period:** 1982-07-01 → 1988-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3172268

## Citation

> US National Institutes of Health, RePORTER application 3172268, IMMUNOLOGICAL DEFECTS IN HUMAN IMMUNODEFICIENT STATES (5R01CA034546-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3172268. Licensed CC0.

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