# METABOLIC STUDIES IN TUMORS WITH L-(13N) AMINO ACIDS

> **NIH NIH R01** · SLOAN-KETTERING INST CAN RESEARCH · 1988 · $162,694

## Abstract

The objectives of the proposed research are to contribute to the
management of cancer patients by using nitrogren-13 labeled
amino acids as imaging agents for assessment of tumor function
and functional response to therapy and to obtain a better
understanding of in vivo tumor metabolism by study of N-13 L-
amino acids.

We shall study the selectivity of in vivo concentration of N-13
derived for intravenously administered L(n-13) tyrosine in human
tumors with aberrant aromatic amino acid metabolism such as
malignant melanoma and neuroblastoma by scintigraphic
measurements.  The specificity of label accumulation from
tyrosine will be determined by sequential studies with L-(N-13)
glutamate.

L-(amideN-13) Glutamine will be evaluated in comparison with
L-(N-13) glutamate for scintigraphic measurement of soft tissue
sarcoma tumor response to therapy in paired, same session
studies.

The efficacy of L-(amide-N-13) glutamine as an imaging agent of
detecting extrahepatic colorectal metastases shall be determined.

The mechanisms of localization and the metabolic fate of the
labeled amino acid shall be studied in transplanted rodent tumors
as a means of interpreting cancer in humans.  The animal studies
will employ imaging procedures as well as dissection of tumors
and analyses of extracts utilizing high performance liquid
chromatography and analyses of extracts utilizing high
performance liquid chromatography and analyses of radioactive
peaks by chemical and enzymatic techiques.  Concurrent studies
will be carried out with N-13 and C-14 labeled L-glutamine and
glutamate to study the fate of the carbon skeleton of the amino
acids and to determine its role as an energy source for tumors.

## Key facts

- **NIH application ID:** 3172338
- **Project number:** 5R01CA034603-05
- **Recipient organization:** SLOAN-KETTERING INST CAN RESEARCH
- **SAM.gov UEI:** KUKXRCZ6NZC2
- **Principal Investigator:** ALAN S GELBARD
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $162,694
- **Award type:** 5
- **Project period:** 1983-12-01 → 1989-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3172338

## Citation

> US National Institutes of Health, RePORTER application 3172338, METABOLIC STUDIES IN TUMORS WITH L-(13N) AMINO ACIDS (5R01CA034603-05). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3172338. Licensed CC0.

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