# NUCLEAR DNA AND MORPHOMETRIC STUDIES OF GYNECOLOGIC CANC

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 1988 · $103,942

## Abstract

The goals of this project are to improve our understanding of
carcinogenesis in gynecologic cancers and to enhance diagnostic and
prognostic accuracies using quantitative analyses.

During the past year, a close relationship between human papillomavirus
infection (genital warts, condylomas) and cervical intraepithelial
neoplasias (squamous dysplasias and carcinomas in situ) has been confirmed
by nuclear DNA quantitation, immunoperoxidase stain for human
papillomavirus capsid antigens, and morphologic analyses.  Using these
techniques, it is possible to demonstrate a transition from cervical
condyloma to neoplasia.  This occurrence is supported by the coexistence of
papillomavirus capsid antigens and aneuploid DNA patterns in 14% of
cervical condylomatous lesions.  The risk of developing cervical
intraepithelial neoplasia is increased in flat rather than exophytic
condylomas, and in condylomas with moderate as compared to mild degree of
nuclear atypia.  These findings support the recent molecular hybridization
studies indicating that several types of human papillomaviruses with
different oncogenicities exist in the female genital tract.  In 51 patients
with clinical stage I or II cervical adenocarcinoma, the survival is most
reliably predicted by the standard deviation of nuclear size (p=0.002), the
DNA ploidy level (p=0.003), the clinical stage (p=0.0072), the percentage
of glandular lumen (p=0.0074), the mean nuclear size (p=0.04), and the
histologic grade (p=0.09).  These findings demonstrate that the prognostic
accuracies can be improved by quantitative analyses over the routine
histologic examinations.  (3)

## Key facts

- **NIH application ID:** 3172690
- **Project number:** 5R01CA034870-07
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **SAM.gov UEI:** RN64EPNH8JC6
- **Principal Investigator:** YAO S FU
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $103,942
- **Award type:** 5
- **Project period:** 1982-09-01 → 1989-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3172690

## Citation

> US National Institutes of Health, RePORTER application 3172690, NUCLEAR DNA AND MORPHOMETRIC STUDIES OF GYNECOLOGIC CANC (5R01CA034870-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3172690. Licensed CC0.

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