# BONE MARROW ASPIRATIONS IN CHILDREN; TREATMENT OUTCOME

> **NIH NIH R01** · CHILDREN'S HOSPITAL OF LOS ANGELES · 1990 · $148,507

## Abstract

Bone marrow aspirations (BMA's) are highly painful and aversive
procedures for pediatric cancer patients.  Previous research by the
investigators has indicated the efficacy of a Cognitive Behavior Therapy
Package (CBTP) in reducing childrens distress during BMA's.  However,
the CBTP is not effective for all children nor does it eliminate
distress for those children who do fine it helpful.  The aim of the
current proposal is to evaluate general anesthesia (nitrous oxide and
halothane) as compared to the CBTP in terms of patient, parent, and
staff distress; cost/benefit ratio and "consumer preference".  Attitudes
of health care providers towards pain in children and towards
psychological intervention vs. general anesthesia for BMA's will be
evaluated as well.

Subjects will be approximately 50 pediatric cancer patients undergoing
at least three consecutive BMA's.  A pre-test or baseline observation of
children's distress during BMA's will be conducted and then children
will be randomly assigned to one of two sequence groups.  All children
will receive both interventions.  Assessment measures for the children
will include:  a) behavioral distress prior to BMA, b) self-reported
fear prior to and after BMA, c) pulse rate upon arrival in treatment
room, d) parent questionnaire of childrens' behavioral after-effects 24
hours following procedure, e) child mental status after BMA, f) physical
side effects (nausea, vomiting, etc.), and g) preference for CBTP vs.
general anesthesia at end of study.  Parent and staff anxiety will be
measured using self-report anxiety measures behavioral observation, and
pulse rates.  Provider attitudes will be measured by a telephone survey.

Data analysis will be conducted using a 2 (sequence group)x2
(intervention condition) repeated measures multivariate analyses of
covariance with pretest scores serving as covariates.  Analyses will
also be conducted to predict which children benefit most from general
anesthesia.

## Key facts

- **NIH application ID:** 3172696
- **Project number:** 5R01CA034871-08
- **Recipient organization:** CHILDREN'S HOSPITAL OF LOS ANGELES
- **SAM.gov UEI:** DVL1CMRMWRN9
- **Principal Investigator:** SUSAN M JAY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $148,507
- **Award type:** 5
- **Project period:** 1982-09-30 → 1991-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3172696

## Citation

> US National Institutes of Health, RePORTER application 3172696, BONE MARROW ASPIRATIONS IN CHILDREN; TREATMENT OUTCOME (5R01CA034871-08). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3172696. Licensed CC0.

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