# ANIMAL MODELS OF AIDS

> **NIH NIH R01** · DANA-FARBER CANCER INST · 1987 · $207,221

## Abstract

Simian Immunodeficiency Virus (SIV) is a primate retrovirus which
causes an immunodeficiency syndrome similar to Acquired
Immunodeficiency Syndrome of man.  The striking similarities
between this virus and the human immunodeficiency virus (HIV) in
terms of both viral structure and resultant clinical disease make
it an attractive model for studying methods by which immunity to
retroviruses can be enhanced.  Early trials with dead virus
vaccines have been disappointing.

Murine models of lethal infection have suggested that antibodies
made to virus specific antibodies or virus specific T cells may
themselves (without antigens) be capable of stimulating immunity
against lethal infections.

This grant will involve a quantitative analysis of the T cell
response to SIV.  In addition, monoclonal antibodies to virus
specific antibodies and T cell clones will be prepared and tested
as inducers of immunity.

## Key facts

- **NIH application ID:** 3172761
- **Project number:** 2R01CA034979-04
- **Recipient organization:** DANA-FARBER CANCER INST
- **SAM.gov UEI:** DPMGH9MG1X67
- **Principal Investigator:** Robert William Finberg
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $207,221
- **Award type:** 2
- **Project period:** 1983-09-30 → 1992-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3172761

## Citation

> US National Institutes of Health, RePORTER application 3172761, ANIMAL MODELS OF AIDS (2R01CA034979-04). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3172761. Licensed CC0.

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