# PERFLUOROCHEMICAL EMULSIONS AS ADJUNCTS TO RADIOTHERAPY

> **NIH NIH R01** · YALE UNIVERSITY · 1992 · $259,071

## Abstract

The long rang goal of this project is to use animal model systems to
evaluate the potential value of perfluorochemical emulsions (PFC-E) as
adjuncts to radiotherapy and to provide the background information
needed to design and implement clinical rials testing these agents. The
studies proposed in this five year renewal application will focus on
studies of second generation PFC-E, having characteristics more
appropriate for use as adjuncts to cancer therapy than the lead compound
(Fluosol) used in our initial laboratory studies and in all past and
ongoing clinical trials.

Studies with transplanted tumors in rats and mice will be extended to
assess fractionated treatment regimens which more closely model those
used in clinical radiotherapy and to determine the optimal parameters
for administering PFC-E during such regimens. The potential value of
multi-agent regimens combining PFC-E with hypoxic cell sensitizers or
drugs toxic to hypoxic cells will be examined, to assess whether the use
of multiple agents directed against hypoxic cells, which may target
different hypoxic cell populations, offer the potential for greater
therapeutic benefit. The biological bases of observed changes in tumor
response will be examined, to assess whether factors other than changes
O2 delivery to tumor cells are important to the effects of the PFC-E.

Effects of second generation perfluorochemical emulsions on the
radiation responses of normal tissues (bone marrow, skin, lung and bone)
will be examined so that the potential for obtaining therapeutic gain
with these agents can be assessed. The effects of these PFC-E on tumor
growth and progression will also be examined, to ensure that these
agents have no unexpected effects on the malignancies. Data from these
studies will be used to help design clinical trials testing second
generation PFC-E as adjuncts to radiotherapy.

## Key facts

- **NIH application ID:** 3172833
- **Project number:** 2R01CA035215-09
- **Recipient organization:** YALE UNIVERSITY
- **SAM.gov UEI:** FL6GV84CKN57
- **Principal Investigator:** SARA ROCKWELL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $259,071
- **Award type:** 2
- **Project period:** 1984-05-01 → 1995-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3172833

## Citation

> US National Institutes of Health, RePORTER application 3172833, PERFLUOROCHEMICAL EMULSIONS AS ADJUNCTS TO RADIOTHERAPY (2R01CA035215-09). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3172833. Licensed CC0.

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