# CASE-CONTROL STUDY OF GALLBLADDER CANCER

> **NIH NIH R01** · UNIVERSITY OF SOUTHERN CALIFORNIA · 1988 · $74,890

## Abstract

We propose an epidemiological case-control study of gallbladder cancer in
Los Angeles County Hispanics for the purpose of evaluating the role of
reproductive history, estrogenic activity, Hispanic diet, Amerindian
inheritance, past GI and metabolic disease, and environmental exposures in
the etiology of that disease.  We will attempt to distinguish between the
causes of gallbladder cancer and the causes fo cholelithiasis.  The cases
will consist of all female cases of gallbladder cancer occurring in Los
Angeles County in three years; controls will consist of matched persons
chosen from the neighborhood of the case and matched cases undergoing
cholecystectomy at the hospital in which the cancer case was diagnosed.  A
personal interview will elicit information about reproductive history,
medical history and drug use, Hispanic diet, and environmental exposures;
blood will be taken to assess evidence of bile lithogenicity, the presence
of Gm allotypes indicating Amerindian inheritance, serologic evidence of
past typhoid infection, and evidences of estrogenic activity.
State-of-the-art techniques, including logistic regression, will be
employed in the analysis.

## Key facts

- **NIH application ID:** 3173037
- **Project number:** 5R01CA035477-05
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **SAM.gov UEI:** G88KLJR3KYT5
- **Principal Investigator:** HERMAN R MENCK
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $74,890
- **Award type:** 5
- **Project period:** 1984-07-01 → 1990-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3173037

## Citation

> US National Institutes of Health, RePORTER application 3173037, CASE-CONTROL STUDY OF GALLBLADDER CANCER (5R01CA035477-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3173037. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*