# MODULATION OF CELLULAR PHOSPHORYLATION BY TUMOR PROMOTER

> **NIH NIH R01** · UNIVERSITY OF CHICAGO · 1990 · $41,823

## Abstract

It is the goal of this study to determine how tumor promoters and other
growth promoting agents modulate hormone receptor action in order to
understand the processes by which these agents influence all growth the
major aim of the research proposed is to characterize the pathways and
mechanisms by which nonTPA-type tumor promoters and nonPDGF-like components
in the media from v-sis transformed cells alter epidermal growth factor
(EGF) receptor properties.  In particular, we will determine the effects of
these agents on EGF receptor binding and phosphorylation, characterize the
mechanism by which these agents modulate EGF receptor action, characterize
the signal transduction pathways, and determine the biological relevance of
these pathways.  Both biochemical and molecular biological approaches will
be used to accomplish these aims.  An understanding of the factors involved
in the regulation of signal-transducing receptors by tumor promoters and
other growth promoting agents will provide valuable information regarding
mechanisms controlling cell proliferation and transformation and their
modulation by environmental factors.

## Key facts

- **NIH application ID:** 3173128
- **Project number:** 3R01CA035541-07S1
- **Recipient organization:** UNIVERSITY OF CHICAGO
- **SAM.gov UEI:** ZUE9HKT2CLC9
- **Principal Investigator:** MARSHA R ROSNER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $41,823
- **Award type:** 3
- **Project period:** 1987-09-01 → 1990-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3173128

## Citation

> US National Institutes of Health, RePORTER application 3173128, MODULATION OF CELLULAR PHOSPHORYLATION BY TUMOR PROMOTER (3R01CA035541-07S1). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3173128. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*