# BLOOD TRANSFUSION AND COLON CANCER RECURRENCE

> **NIH NIH R01** · MOUNT SINAI SCHOOL OF MEDICINE OF CUNY · 1987 · $45,452

## Abstract

The immune modulating effect of blood transfusions which are beneficial in
the renal transplant situation may be detrimental to patients undergoing
surgery for malignancy.  Pretransplant transfusion is associated with
impaired delayed hypersensitivity responses and prolonged kidney graft
survival.  Impaired delayed hypersensitivity in preoperative cancer
patients is associated with advanced disease and early recurrence following
surgery.  A retrospective study of colon cancer recurrence following
perioperative blood transfusion indicates that transfusions are associated
with early recurrence.  The profound clinical significance of this finding
demands prompt confirmation.  We propose a prospective study of colon
cancer recurrence following perioperative transfusion.  In addition,
because operated patients with malignancies will continue to require
transfusions in preparation for surgery or in compensation for
intraoperative blood loss, the effect of frozen blood on colon cancer
recurrence will be evaluated in patients who require transfusion.  Frozen
blood does not cause HLA isosensitization when administered to dialysis
patients and does not prolong kidney graft survival.  Frozen blood, by not
causing immune modulation in cancer patients, may not be associated with
early recurrence.  Recurrence following standard transfusion, transfusion
of frozen blood, and no transfusion will be evaluated controlling for
stage, timing, procedure, postoperative therapy, and anesthetic.  The
results of the study will evaluate the influence of perioperative
transfusion on recurrence following colorectal surgery.  The possible role
of frozen blood in ameliorating the effect of transfusion on colon cancer
recurrence will also be evaluated.

## Key facts

- **NIH application ID:** 3173145
- **Project number:** 5R01CA035558-05
- **Recipient organization:** MOUNT SINAI SCHOOL OF MEDICINE OF CUNY
- **Principal Investigator:** PAUL I TARTTER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $45,452
- **Award type:** 5
- **Project period:** 1983-08-01 → 1988-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3173145

## Citation

> US National Institutes of Health, RePORTER application 3173145, BLOOD TRANSFUSION AND COLON CANCER RECURRENCE (5R01CA035558-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3173145. Licensed CC0.

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