# VULVAR CANCER--EPIDEMIOLOGY, BIOCHEMISTRY, & IMMUNOLOGY

> **NIH NIH R01** · FRED HUTCHINSON CANCER RESEARCH CENTER · 1988 · $114,078

## Abstract

This is a proposal to continue a case-control study to test the hypothesis
that infection with human papilloma virus (HPV) is related to an increased
risk of vulvar cancer.  The study will be conducted in three of the
counties of Western Washington that are covered by the population-based
Cancer Surveillance System (CSS), a tumor registry that participates in the
Surveillance Epidemiology and End Results Program (SEER) of the National
Cancer Institute.  Female residents who are diagnosed with invasive or
in-situ vulvar cancer during January 1986 - June 1990 (approximately 200
cases) will be identified and invited to participate.  Cases and two
control groups will be interviewed regarding a history of
sexually-transmitted diseases, as well as other known risk factors for
vulvar cancer.  Tissue specimens will be collected from each case and from
a control group of women who were surgically treated for certain benign
vulvar conditions.  These samples will be examined using molecular
hybridization techniques for specific types of HPV.  A second
population-based random digit dialed control group will be included, but
tissue specimens will not be collected from this group.  Blood samples will
be collected for all cases and controls and analyzed for evidence of prior
exposure to sexually transmitted viral infections (a sample of blood will
be stored for analysis when a test for HPV becomes available).  The
information from these cases and controls will be added to that of the
approximately 210 cases and 300 controls interviewed under the current
grant to facilitate independent analyses of in-situ and invasive vulvar
cancer assessing the relative risks associated with specific HPV type,
allowing for confounding and interactions with other exposures these women
may have had.

## Key facts

- **NIH application ID:** 3173408
- **Project number:** 5R01CA035881-05
- **Recipient organization:** FRED HUTCHINSON CANCER RESEARCH CENTER
- **SAM.gov UEI:** HMSNCM57QNR5
- **Principal Investigator:** JANET R DALING
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $114,078
- **Award type:** 5
- **Project period:** 1983-09-15 → 1989-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3173408

## Citation

> US National Institutes of Health, RePORTER application 3173408, VULVAR CANCER--EPIDEMIOLOGY, BIOCHEMISTRY, & IMMUNOLOGY (5R01CA035881-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3173408. Licensed CC0.

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