# EXPRESSION AND STRUCTURE OF INVERTEBRATE ONCOGENES

> **NIH NIH R01** · WORCESTER FOUNDATION FOR BIOMEDICAL RES · 1992 · $21,000

## Abstract

Mutations in the Drosophila EGF receptor gene affect a range of vital
and developmental processes. The long-term goal of this research program
is to define the role(s) of growth factor receptor tyrosine kinases in
development through detailed genetic and molecular genetic studies in
this model system. It is hoped that the results of these studies can be
extended to vertebrate systems and thus shed light on the roles of
cellular and transforming growth factor receptor tyrosine kinases in
normal development and in neoplastic disease. The Specific Aims of the
current proposal are: (1). To complete the genetic characterization of
extragenic mutations that suppress the Ellipse (Elp) class of EGF
receptor mutations. Elp alleles manifest a dominant rough eye phenotype.
Five suppressor gene mutations induced by P element mutagenesis have
been isolated and will be analyzed with respect to interaction with
recessive EGF receptor gene mutations and with each other. (2). To
analyze a subset of the Elp suppressors at the molecular level. On the
basis of the genetic tests, certain of the Elp suppressor mutations will
be molecularly cloned and sequenced to learn the structure/identity of
elements of the EGF receptor signaling pathway. (3). To identify genes
acting as extragenic suppressors of recessive DER gene mutations in
tissues other than the eye. Mutations of this class would represent
gain-of-function mutations in elements of the DER signaling pathway that
may not function in the eye. These results will reveal whether the same,
different, or partially overlapping set of elements functions in the EGF
receptor signaling pathway in different tissues. (4). To isolate new
alleles of the Elp class in a defined genetic background to define the
mechanism or mechanisms that can activate the dominant mutant phenotype
in EGF receptor. Genetic tests will be carried out to assess the
potential for variability in the Elp phenotype. Companion studies at the
molecular level will define the structural changes in the protein
accompanying phenotypic variation.

## Key facts

- **NIH application ID:** 3173431
- **Project number:** 2R01CA035911-07A2
- **Recipient organization:** WORCESTER FOUNDATION FOR BIOMEDICAL RES
- **Principal Investigator:** EARL F BARIL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $21,000
- **Award type:** 2
- **Project period:** 1984-08-01 → 1993-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3173431

## Citation

> US National Institutes of Health, RePORTER application 3173431, EXPRESSION AND STRUCTURE OF INVERTEBRATE ONCOGENES (2R01CA035911-07A2). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3173431. Licensed CC0.

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