# ULTRASONIC PROPAGATION PROPERTIES IN INTACT TISSUE

> **NIH NIH R01** · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 1988 · $223,504

## Abstract

The principal objectives of the proposed research are to determine the
ultrasonic propagation properties in intact tissue and to correlate these
parameters to those obtained with the ultrasonic computer-assisted
tomographic technique.  Specifically, ultrasonic properties of attenuation,
velocity, and absorption will be compared to the tissue constituents water,
total protein, collagen, and fat with the view of determining the influence
of such constituents upon ultrasonic propagation properties.

Four measurement techniques will be employed to determine the spatial
distribution of ultrasonic attenuation, velocity, and absorption.  They
include a radiation force balance technique, the transient thermoelectric
technique, the scanning laser acoustic microscope technique, and ultrasonic
computer-assisted tomographic technique.

Collaboration between the Ultrasonics Research Laboratory at Mayo Clinic
and the Bioacoustics Research Laboratory at the University of Illinois will
continue to 1) develop methods for calibrating basic measurements at both
laboratories, 2) result in evaluation at both labs of human tissue taken
from the same organ, and of calibration phantoms.

## Key facts

- **NIH application ID:** 3173536
- **Project number:** 5R01CA036029-09
- **Recipient organization:** UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
- **SAM.gov UEI:** Y8CWNJRCNN91
- **Principal Investigator:** William D. O'Brien
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $223,504
- **Award type:** 5
- **Project period:** 1983-06-01 → 1989-09-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3173536

## Citation

> US National Institutes of Health, RePORTER application 3173536, ULTRASONIC PROPAGATION PROPERTIES IN INTACT TISSUE (5R01CA036029-09). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3173536. Licensed CC0.

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