# FAT NUCLEOSIDES AND NUCLEOTIDES

> **NIH NIH R01** · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · 1989 · $114,993

## Abstract

Synthesis, chemistry and biochemistry of a family of "fat"
nucleosides and nucleotides possessing the following 5:7-fused
heterocyclic base systems will be studied: I)
imidazo(4,5,e)(1,3,4)triazepine; II) imidazo(4,5-e)(1,4)diazepine;
and III) imidazo(4,5,d)(1,3)diazepine.  The novel rearrangement
discovered in the heterocyclic system of category I will be further
explored for wide synthetic utility.  The mono- and diphosphate
derivatives of nucleosides of category II will be prepared.  The
diphosphates will be polymerized by using the enzyme
polynucleotide phosphorylase and the resulting homopolymer
templates will be evaluated for substrate/inhibitory activity
against Moloney murine leukemia virus (M-MuLV) reverse
transcriptase.  These studies will be extended to "fat"
nucleoside/nucleotide systems of categories I & III.  The target
and intermediate nucleosides and heterocycles will be screened
for potential antitumor activity by the National Cancer Institute.
The ongoing collaborative arrangements with Professor E.  De
Clercq of Katholieke University, Leuven, Belgium will enable
testing of the above compounds for antiviral activity in a broad
range of viral assay systems.  Preliminary studies on the 5:8-fused
heterocylic systems will be continued.  As a secondary goal,
double helical complexes will be prepared by pairing the above
"fat" nucleotide homopolymers with appropriate pyrimidine
counterparts, and investigated for stability, stacking interactions
and conformational characteristics.

## Key facts

- **NIH application ID:** 3173660
- **Project number:** 5R01CA036154-05
- **Recipient organization:** UNIVERSITY OF MARYLAND BALTIMORE COUNTY
- **SAM.gov UEI:** RNKYWXURFRL5
- **Principal Investigator:** Ramachandra S Hosmane
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $114,993
- **Award type:** 5
- **Project period:** 1984-07-01 → 1990-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3173660

## Citation

> US National Institutes of Health, RePORTER application 3173660, FAT NUCLEOSIDES AND NUCLEOTIDES (5R01CA036154-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3173660. Licensed CC0.

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