# ASSESSMENT OF MALIGNANCY BY H-1 NMR SPECTROSCOPY

> **NIH NIH R01** · BETH ISRAEL DEACONESS MEDICAL CENTER · 1988 · $148,268

## Abstract

Recently our laboratory, as well as others, have been studying the
non-water proton NMR signals of normal and malignant tissue.  In
many cases larger and more definitive differences are seen in the
relaxation parameters of non-water resonances, arising largely
from lipid components of tissue, making characterization of
malignancy more reliable.  We have been able to observe aliphatic
proton resonances in all types of tissue and plasma studied and
have begun the correlation of their NMR relaxation parameters
with malignancy.

It is the overall goal of the studies proposed in this application to
further characterize the NMR properties of the non-water
resonances of tumors and normal tissue and define certain aspects
of both the biological and biophysical mechanism responsible for
the unique features of these resonances in malignancy.  The data
from these studies will be used to test the hypotheses that:  1) the
NMR signal and its relaxation parameters arising from resolvable
aliphatic resonances is a more sensitive and specific indicator of
malignancy than are the composite proton resonance or the water
resonance itself; and 2) that an understanding of certain aspects
of the mechanism which produces differences in these properties
of the aliphatic resonance will be of value to the classification of
stages of malignancy and its regression as well as, perhaps,
offering new understanding of certain biophysical and biochemical
aspects of the disease process itself.

## Key facts

- **NIH application ID:** 3173829
- **Project number:** 5R01CA036276-05
- **Recipient organization:** BETH ISRAEL DEACONESS MEDICAL CENTER
- **SAM.gov UEI:** C1CPANL3EWK4
- **Principal Investigator:** ERIC T FOSSEL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $148,268
- **Award type:** 5
- **Project period:** 1984-01-01 → 1990-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3173829

## Citation

> US National Institutes of Health, RePORTER application 3173829, ASSESSMENT OF MALIGNANCY BY H-1 NMR SPECTROSCOPY (5R01CA036276-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3173829. Licensed CC0.

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