# RAS GENE MUTATION TIME AND STRUCTURE IN MOUSE LYMPHOMAS

> **NIH NIH R01** · NEW YORK UNIVERSITY · 1990 · $194,936

## Abstract

We will continue to study the model system of murine induced thymic
lymphomas by carcinogenic agents.  Since we have already demonstrated that
K and N-ras oncogenes are consistently associated with these tumors, we
will concentrate first in the analysis of the balance or imbalance between
the mutated, allele and its normal counteerpart in these tumors.  We will
study also the structure of the mouse N-ras oncogene determining the number
and location of its untranslated exons and their function using in vitro
mutagenesis and gene transfer.  We will approach the controversial problem
of ras being an early or late event in tumorigenesis by using
transplantation of preleukemic cells from a single donor into several
recipients and analyzing if the subseqent tumors have all the same oncogene
mutation.  Finally, and conceptually related to the previous experiments we
will attempt to create transgenic mice with an activated N-ras oncogene,
under the influence of an inducible promoter, to determine if it can, alone
or in combination with other factors, produce malignancies when it is
timely induced to express.

## Key facts

- **NIH application ID:** 3173882
- **Project number:** 5R01CA036327-07
- **Recipient organization:** NEW YORK UNIVERSITY
- **SAM.gov UEI:** NX9PXMKW5KW8
- **Principal Investigator:** ANGEL PELLICER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $194,936
- **Award type:** 5
- **Project period:** 1984-01-01 → 1991-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3173882

## Citation

> US National Institutes of Health, RePORTER application 3173882, RAS GENE MUTATION TIME AND STRUCTURE IN MOUSE LYMPHOMAS (5R01CA036327-07). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3173882. Licensed CC0.

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