# REPAIR AND RECOMBINATION IN RADIATION-SENSITIVE CELLS

> **NIH NIH R01** · UNIVERSITY OF TX MD ANDERSON CAN CTR · 1991 · $123,030

## Abstract

The objective of the research program is to understand cellular responses
to radiation and chemical injury.  Among these responses are processes of
DNA repair and DNA rearrangement through homologous and non-homologous
recombination pathways.  It is likely that DNA repair and DNA recombination
participate in cellular and genetic changes that occur in carcinogenesis.
We intend to study the role of DNA damage, including UV,
N-acetoxy-acetylaminofluorene, and 6-4 pyrimidine-pyrimidone adducts in
homologous and non-homologous recombination processes in mammalian cells.
We will study the basis for differences in response to UV damage in human
and Chinese hamster ovary cell lines using DNA-mediated gene transfer
methods.  Somatic cell hybrids and UV-sensitive mammalian cell mutants will
be used in these studies.  Specially-constructed DNA sequences with
fragments of mammalian genes will be introduced into mammalian cells by
transfection and their recombination will be studied.  The effects of
damaging these gene fragments and pre-exposing cells to radiation will be
investigated.  The knowledge we will gain from these studies is directly
relevant to the repair of DNA, cell recovery from DNA damaging treatments,
mutagenesis, and carcinogenesis.

## Key facts

- **NIH application ID:** 3173923
- **Project number:** 5R01CA036361-08
- **Recipient organization:** UNIVERSITY OF TX MD ANDERSON CAN CTR
- **SAM.gov UEI:** S3GMKS8ELA16
- **Principal Investigator:** Rodney S Nairn
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $123,030
- **Award type:** 5
- **Project period:** 1983-12-01 → 1992-09-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3173923

## Citation

> US National Institutes of Health, RePORTER application 3173923, REPAIR AND RECOMBINATION IN RADIATION-SENSITIVE CELLS (5R01CA036361-08). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3173923. Licensed CC0.

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