# LINKAGE ANALYSIS AND MULTIPLE LOCI

> **NIH NIH R01** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 1991 · $130,423

## Abstract

This research is designed to investigate the efficient localization and
ordering of major genes through linkage analysis.  Although new gene
mapping methods and programs have emerged, significant capabilities are
still lacking and many of the statistical concepts are dated.  Gene mapping
can be divided into two phases:  1) initial assignment of a gene to a
chromosomal region, and 2) assignment of gene order and map distance of the
disease locus to all of the markers.  The issues of significance and
efficiency are different for these phases.  In the first phase, we are
testing for linkage between the disease locus and well-spaced highly
polymorphic markers.  Three locus evaluation of expected LOD scores and
actual LOD scores are sufficient.  We will investigate significance levels
of the three locus analysis for testing linkage on saturated maps.  For
fine mapping we will compute expected LOD scores and LOD scores for gene
order with multiple loci.  We will also establish significance levels for
comparison of orders.  The preliminary LOD scores sufficient to justify a
switch in strategy from localization to establishing order will be
described.  As the set of tools for calculating expected LOD scores and LOD
scores are investigated, a knowledge-based expert system will be developed
which will integrate these tools with the appropriate databases and rules.
The system will be an automated tool assisting in designing the
experiments, evaluating data from the experiments, and redesigning the
experiment in light of the preliminary results.  Thus, the large number of
linkage experiments carried out in the near future can be performed
efficiently.

## Key facts

- **NIH application ID:** 3173928
- **Project number:** 5R01CA036362-08
- **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- **SAM.gov UEI:** LL8GLEVH6MG3
- **Principal Investigator:** MARK SKOLNICK
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $130,423
- **Award type:** 5
- **Project period:** 1984-01-01 → 1992-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3173928

## Citation

> US National Institutes of Health, RePORTER application 3173928, LINKAGE ANALYSIS AND MULTIPLE LOCI (5R01CA036362-08). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3173928. Licensed CC0.

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