# GENETIC-EPIDEMIOLOGIC STUDY OF BILATERAL BREAST CANCER

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 1990 · $117,567

## Abstract

We propose to evaluate the genetic component in the etiology of breast
cancer with segregation and linkage analyses. Index cases will be cases with
early (<50 years of age) bilateral breat cancer who are currently
participating in a study by the USC school of medicine. We will administer a
more detailed geneology questionnaire to all index cases, confirm the
diagnoses of all possible cases of breast cancer among relatives and obtain
one blood sample from each member of multiplex nuclear families.  Twenty-
eight genetic makers will be determined in the laboratory of Dr. Robert
Sparkes at UCLA. By the end of the study, we anticipate having approximately
211 index cases and 50 multiplex families.

Segregation analysis will be conducted to test whether or not the
distribution of breast cancer in families is consistent with a breast cancer
susceptibility gene, and, if so which model best fits our data. We will
use an extension of Morton and Maclean's mixed model (MIXMOD) that allows
for incomplete ascertainment, selection of certain kinds of multiplex
pedigrees, and variable ages of onset.

We will then test for linkage between a presumed breast cancer
susceptibility gene and 28 genetic marker loci. We will utilize the program
LIPED, which can incorporate into the analysis different recombination
values in males and females, and incomplete penetrance, which includes age
of onset corrections.

## Key facts

- **NIH application ID:** 3173947
- **Project number:** 2R01CA036387-07
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **SAM.gov UEI:** RN64EPNH8JC6
- **Principal Investigator:** ROBERT William HAILE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $117,567
- **Award type:** 2
- **Project period:** 1984-01-01 → 1993-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3173947

## Citation

> US National Institutes of Health, RePORTER application 3173947, GENETIC-EPIDEMIOLOGIC STUDY OF BILATERAL BREAST CANCER (2R01CA036387-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3173947. Licensed CC0.

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