# CELL GENETIC DAMAGE AT LOW DOSE AND LOW DOSE RATE

> **NIH NIH R01** · COLORADO STATE UNIVERSITY · 1991 · $242,659

## Abstract

Our long-term goal is to provide a comprehensive picture of the spectrum
of genetic damages produced in mammalian cells by ionizing radiation (as
a model) at the low doses (<10 R) and dose rates relevant to most human
exposures, and to develop quantitative methodologies to assess the
impact of genetic damage on cancer and other human disease.  The
collaboration between the Eleanor Roosevelt Institute for Cancer
Research (ERICR), Denver, and the Department of Radiology and Radiation
Biology, Colo. State Univ. (CSU), Ft. Collins, has greatly facilitated
our interrelated studies of the overall genetic effects of low-level
exposure.  The groups at ERICR and CSU have experience in analysis of
mutation, and chromosome aberrations, respectively.  The goal of this
proposal is to measure gene and chromosome mutations, on the one hand,
and chromosome aberrations, on the other, so as to illuminate
relationships between them; to begin to define the role of DNA repair;
to analyze mutation at the DNA level, and to develop theoretical models
to relate them.  Specifically we will:  (1) employ the AL hamster hybrid
cell method to quantify gene and chromosome mutation and cytogenetically
examine AL mutants to correlate chromosome aberrations with mutation;
(2) establish how varying the dose rate alters the frequency and kinds
of mutants and aberrations produced; (3) Begin, by DNA restriction
analysis, to investigate mechanisms of mutagenesis; (4) extend all these
studies to new human-hamster hybrids that contain additional human
chromosomes which will increase target size and permit assessment of
translocation and nondisjunction using genetic and in situ fluorescence
cytogenetics techniques; (5) carry out these studies on other hybrids
defective in particular aspects of repair; and (6) continue to develop
and experimentally test mathematical models relating dose response
relationships of cell-killing, and mutation and especially
translocations.

## Key facts

- **NIH application ID:** 3174025
- **Project number:** 5R01CA036447-06
- **Recipient organization:** COLORADO STATE UNIVERSITY
- **SAM.gov UEI:** LT9CXX8L19G1
- **Principal Investigator:** CHARLES A. WALDREN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $242,659
- **Award type:** 5
- **Project period:** 1984-09-01 → 1994-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3174025

## Citation

> US National Institutes of Health, RePORTER application 3174025, CELL GENETIC DAMAGE AT LOW DOSE AND LOW DOSE RATE (5R01CA036447-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3174025. Licensed CC0.

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