# RADIATION ACTIVATION OF ONCOGENES

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA AT DAVIS · 1988 · $130,831

## Abstract

Our goal is to explore a central mechanism by which cancer may arise from
irradiation and other causes.  In this scheme cancer results from an
augmented or inappropriate expression of normal cellular genes (oncogenes)
brought on by chemicals, radiation, viruses or aging.  Some of these
cellular cancer genes have been identified and characterized in
retroviruses and others have been isolated by the DNA mediated 3T3 cell
transformation technique.  Highly specific molecularly cloned probes have
been constructed that are now available for measuring expression of these
oncogenes at the DNA and RNA level.  By studying radiation and chemical
induced leukemias in RF/Un mice and mammary tumors in BALB/cfC3H, we plan
to address 7 unanswered questions:  (1) Do radiation-induced neoplasms
contain activated oncogenes?; (2) Are radiation-induced oncogenes related
to known viral or cellular oncogenes?; (3) Are radiation-induced oncogenes
the same in neoplasms from different target tissues?; (4) Do different
carcinogens (chemical, viral, radiation) induce the same oncogenes in a
given target tissue?; (5) At what point in the neoplastic progression are
the oncogenes expressed?; (6) Does radiation induce homologous oncogenes in
different species?; and (7) What is the mechanism of irradiation induced
activation of oncogenes?

## Key facts

- **NIH application ID:** 3174110
- **Project number:** 5R01CA036493-05
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **SAM.gov UEI:** TX2DAGQPENZ5
- **Principal Investigator:** Robert D Cardiff
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $130,831
- **Award type:** 5
- **Project period:** 1983-12-01 → 1989-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3174110

## Citation

> US National Institutes of Health, RePORTER application 3174110, RADIATION ACTIVATION OF ONCOGENES (5R01CA036493-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3174110. Licensed CC0.

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