# ANTINEOPLASTIC AGENTS FROM MARINE ORGANISMS

> **NIH NIH R01** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 1990 · $140,452

## Abstract

Seventy-nine marine organisms (51 tunicates, 20 sponges, and 8 molluscs)
were collected and evaluated as potential sources of new chemotherapeutic
agents.  Extracts from 33 organisms exhibited cytotoxicity and 8 inhibited
microbes.

Isolation and structure studies have been initiated with several of these
organisms, Peronia peronii (L1210, IC50 0.5 mug/ml), Eudistoma olivaceum
(L1210, IC50 0.33 mug/ml) and Dolabella auricularia (L1210, IC50 0.01
mug/ml).  Several active metabolites were isolated and structure studies
are in progress.

During the three year period of this grant isolation work will be
undertaken on the remaining active species from the collection noted above.

## Key facts

- **NIH application ID:** 3174230
- **Project number:** 5R01CA036622-08
- **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- **SAM.gov UEI:** LL8GLEVH6MG3
- **Principal Investigator:** Chris M. Ireland
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $140,452
- **Award type:** 5
- **Project period:** 1983-09-01 → 1993-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3174230

## Citation

> US National Institutes of Health, RePORTER application 3174230, ANTINEOPLASTIC AGENTS FROM MARINE ORGANISMS (5R01CA036622-08). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3174230. Licensed CC0.

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