# CELLULAR AND MOLECULAR EVENTS IN B LYMPHOCYTE ACTIVATION

> **NIH NIH R01** · DUKE UNIVERSITY · 1988 · $169,691

## Abstract

The immune response results from the interactions of lymphocytes of many
specificities and functions.  One of these, the helper T cell, is required
for the optimal expression of the functions of other subsets of T cells as
well as B lymphocytes.  The experiments are designed to further our
understanding of helper T-cell function and the mechanisms that control
their interactions with B lymphocytes.  First, we are evaluating the role
of interleukin-2 in the responses of B lymphocytes.  We have identified a
novel Thy-1+ cell that arises in cultures containing interleukin-2, whose
function may be to induce resting B cells to enter cell cycle.  We are
continuing studies directed at understanding this population.  Second, we
are evaluating the function of surface immunoglobulin and class II
molecules in the triggering of B lymphocytes.  Using a B-cell lymphoma that
expressed I-A snd I-E molecules but utilizes only I-E molecules as
triggering receptors, we are evaluating the relative mobilities of these
molecules in the membrane, their numbers, and the dynamics of these
molecules in the membrane of unactivated and activated cells.  Third, we
are investigating the selective use of the I-E molecule as a triggering
receptor and its relationship with the expression of certain immunoglobulin
V regions during the immune response (i.e., immune response gene control of
B-cell idiotypes).  Together, these studies will provide information
necessary to understand the regulation of interactions of functionally
distinct subpopulations of lymphocytes, the basis of specificity in the
immune response, and the selection of the B-lymphocyte repertoire.  The
results of these experiments will also provide insights into the nature of
aberrant lymphocyte responses and growth.  (LB)

## Key facts

- **NIH application ID:** 3174243
- **Project number:** 5R01CA036642-08
- **Recipient organization:** DUKE UNIVERSITY
- **SAM.gov UEI:** TP7EK8DZV6N5
- **Principal Investigator:** RONALD B CORLEY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $169,691
- **Award type:** 5
- **Project period:** 1987-07-01 → 1989-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3174243

## Citation

> US National Institutes of Health, RePORTER application 3174243, CELLULAR AND MOLECULAR EVENTS IN B LYMPHOCYTE ACTIVATION (5R01CA036642-08). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3174243. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*