# ONCOGENES IN PHYSIOLOGIC AND PATHOLOGIC STATES

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 1992 · $218,115

## Abstract

Proto-oncogenes and tumor suppressor genes represent a cohort of cellular
genes which are known to play central roles in the normal growth and
proliferation of vertebrate cells.  Increasing evidence indicates that
alterations in these genes play a role in the induction and/or
maintenance of many if not all human malignancies.

The purpose of this program is to continue work ongoing over the past
eight years to identify and characterize alterations in these genes in a
variety of human malignancies.  The program is designed to screen human
tumor tissues using nucleic acid and antibody probes for genes Of
interest to detect patterns of alterations in various groups of
malignancies.  As a result of this approach the program has been
effective in identifying proto-oncogene alterations which may be
important in the pathogenesis of human breast and ovarian cancers and has
used this information as well as information generated by other
laboratories to generate reagents to study the role these alterations
play on the biology of the diseases in which they occur.  We propose to
use these studies to gain new insights into the diagnosis, prognosis and
treatment of human malignancies.

## Key facts

- **NIH application ID:** 3174403
- **Project number:** 2R01CA036827-09
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **SAM.gov UEI:** RN64EPNH8JC6
- **Principal Investigator:** DENNIS J SLAMON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $218,115
- **Award type:** 2
- **Project period:** 1984-07-01 → 1997-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3174403

## Citation

> US National Institutes of Health, RePORTER application 3174403, ONCOGENES IN PHYSIOLOGIC AND PATHOLOGIC STATES (2R01CA036827-09). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3174403. Licensed CC0.

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