# ONCOGENES IN PHYSIOLOGIC AND PATHOLOGIC STATES

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 1989 · $166,062

## Abstract

Proto-oncogenes are a cohort of cellular genes which are avidly
conserved across a broad span of vertebrate evolution.  Evidence
now exists that these genes play a role in normal cellular
processes such as growth and differentiation.  In addition,
considerable circumstantial evidence exists linking various
alterations in these genes to the induction and/or maintenance of
human malignancies.   We have been involved in the study of the
expression of proto-oncogenes in physiologic states (murine
development) and pathologic states (human malignancies).

We propose to continue this work using reagents generated in our
laboratory during the preceeding funding period, as well as
reagents from other laboratories.  The general approach is
multifaceted, and is as follows.  Firstly, we will attempt to obtain
information on some aspects of the biologic properties and
functions of those proto-oncogenes for which we have useful
reagents (i.e., N-myc, c-myb, and c-fos); secondly, we plan to
conduct studies on the time-related and tissue-specific expression
of these and other proto-oncogenes during murine development;
thirdly, we will expand previous studies on the role of the N-myc,
c-myb and HER-2/neu proto-oncogenes in specific human
malignancies (i.e., neuroblastoma and small cell carcinoma of the
lung, acute leukemias, and carcinoma of the breast, respectively);
and finally, we propose to conduct a survey of common human
malignancies for alterations in proto-oncogenes at the DNA level
and/or their expression at the RNA and protein levels, in an
attempt to correlate any observed alterations with specific tumor
types, or with various clinical parameters of a given tumor.

## Key facts

- **NIH application ID:** 3174407
- **Project number:** 5R01CA036827-06
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **SAM.gov UEI:** RN64EPNH8JC6
- **Principal Investigator:** DENNIS J SLAMON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $166,062
- **Award type:** 5
- **Project period:** 1984-07-01 → 1992-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3174407

## Citation

> US National Institutes of Health, RePORTER application 3174407, ONCOGENES IN PHYSIOLOGIC AND PATHOLOGIC STATES (5R01CA036827-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3174407. Licensed CC0.

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