# THE SYNTHESIS OF RAVIDOMYCIN AND OF ANALOGUES

> **NIH NIH R01** · UNIVERSITY OF ALABAMA IN TUSCALOOSA · 1987 · $70,430

## Abstract

The total synthesis of the antitumor drug ravidomycin is proposed.  The
naphthalene aglycone of this C-glycoside is also found in toromycin and
gilvogarcin V.  The plan is to append the deoxyaminoaltrose sugar onto a
properly functionalized benzoquinone.  The synthetic methodology which is
envisioned for the connection of ring D is a Meerwein arylation or a
palladium mediated arylation of benzoquinone.

## Key facts

- **NIH application ID:** 3174459
- **Project number:** 5R01CA036868-03
- **Recipient organization:** UNIVERSITY OF ALABAMA IN TUSCALOOSA
- **SAM.gov UEI:** RCNJEHZ83EV6
- **Principal Investigator:** THOMAS C MC KENZIE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $70,430
- **Award type:** 5
- **Project period:** 1985-05-01 → 1988-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3174459

## Citation

> US National Institutes of Health, RePORTER application 3174459, THE SYNTHESIS OF RAVIDOMYCIN AND OF ANALOGUES (5R01CA036868-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3174459. Licensed CC0.

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