# IN UTERO DES EXPOSURE: CANCER AND MEDICAL ILLNESSES

> **NIH NIH R01** · MAYO CLINIC ROCHESTER · 1990 · $112,955

## Abstract

The purpose of this project is to add approximately 22,500 person years for
the detection of cancer and other major medical illnesses among the 5,464
women who have previously been enrolled in the DESAD Project.  This
continued surveillance will enable us to accomplish five specific aims:  to
determine the magnitude of the excess of squamous neoplasia in exposed over
unexposed women and to determine if the increased risk continues over the
next five years, to determine if the risk of adenocarcinoma increases
during the next five years, to determine the rates of serious medical
illnesses in the DES exposed women and to compare these rates with the
control groups and published age specific incidence rates for the same
diseases, to determine the frequency of abdominal and gynecologic surgery
among DES exposed women and to compare these rates with the unexposed
controls and the rates available from the National Center for Health
Statistics, and to maintain contact with the DESAD Project exposed cohort
at minimal expense.

These aims will be accomplished by soliciting information by the method of
mailed questionnaire.  Each participant will be questioned annually
concerning the diagnosis of medical diseases or the performance of surgical
procedures.  Previous experience of the DESAD cohort has indicated that in
excess of 90 percent of the women previously enrolled in the project can be
expected to comply with the requests for information.  The sample size
considerations are explained in detail in the project and indicate that it
will be possible to detect, with a power of .9, a two-fold difference in
the rates of many common medical diseases and surgical procedures at the
p=.05 level.

## Key facts

- **NIH application ID:** 3174463
- **Project number:** 3R01CA036873-05S1
- **Recipient organization:** MAYO CLINIC ROCHESTER
- **SAM.gov UEI:** Y2K4F9RPRRG7
- **Principal Investigator:** PETER C O'BRIEN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $112,955
- **Award type:** 3
- **Project period:** 1984-08-15 → 1991-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3174463

## Citation

> US National Institutes of Health, RePORTER application 3174463, IN UTERO DES EXPOSURE: CANCER AND MEDICAL ILLNESSES (3R01CA036873-05S1). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3174463. Licensed CC0.

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