# THE EFFECT OF HYPERTHERMIA ON NORMAL TISSUE BLOOD FLOW

> **NIH NIH R01** · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · 1987 · $155,327

## Abstract

Knowledge of tissue blood flow is important for effective
hyperthermia treatment.  Numerous investigators have suggested
that blood flow in normal and tumor tissue changes during
treatment and knowledge of the kinetics of these changes is
important for accurate treatment planning.  Tissue vasodilation
during treatment is a complex process.  The resultant blood flow
during a fractionated treatment course changes from one
treatment to another.  As a result, the delineation of the
underlying physiologic mechanisms responsible for these changes
becomes increasingly important.

This investigation will focus on establishing the kinetics of normal
tissue blood flow in response to different fractionation schemes.
Normal muscle tissue will be heated with either 45 degrees
Centigrade or 43 degrees Centigrade hyperthermia for periods of
up to one hour and blood flow in treated tissue will be measured
during the treatment with different radioactively labeled
microspheres.

The response of tissue blood flow to different fractionation
schemes will be evaluated for the two different tempatures.
Previous data suggest that the transient tissue blood flow during
four different hyperthermia fractions delivered at 72 hour
intervals changes from treatment to treatment.  This investigation
will be an extension of the previous work and will examine blood
flow changes during 24 hour and 168 hour fractionation intervals.
To provide further elucidation of the underlying physiological
mechanisms responsible for blood flow changes, different sizes of
radioactively labeled microspheres will be employed during the
different fractionation sequences.  By comparison of blood flows
measured with different sizes of radioactive microspheres in the
same animal, an indication will be provided as to the changes in
vessel diameter and response of the central mechanism during
treatment.

Correlation of these values to mathematical models will be
preformed as they have been in the past.  This will continue to
allow measurement of tissue blood flow in spontaneous animal
tumors treated with hyperthermia.  A well developed network for
accessing tumor bearing animals exists at the Medical College of
Ohio and measurements of tumor and normal tissue blood flow
under different fractionation schemes will be performed in vivo.

## Key facts

- **NIH application ID:** 3174525
- **Project number:** 2R01CA036899-04
- **Recipient organization:** UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS
- **SAM.gov UEI:** M9ACC5DQCNL6
- **Principal Investigator:** ANDREW J MILLIGAN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $155,327
- **Award type:** 2
- **Project period:** 1984-05-01 → 1988-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3174525

## Citation

> US National Institutes of Health, RePORTER application 3174525, THE EFFECT OF HYPERTHERMIA ON NORMAL TISSUE BLOOD FLOW (2R01CA036899-04). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3174525. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*