# DIAGNOSTIC RADIOLOGY-IMAGING--CHEMOTHERAPY-BRAIN TUMOR

> **NIH NIH R01** · JOHNS HOPKINS UNIVERSITY · 1988 · $28,150

## Abstract

The animal research outlined in this proposal is directed towards extending
clinical Diagnostic Radiology imaging (Computer Axial Tomography-CT and
Nuclear Magnetic Resonance-NMR) and Interventional Radiology (arterial
infusion chemotherapy) to improve the treatment of brain tumors.  More
specifically, work outlined in this proposal is intended to use a new
animal brain tumor model to quantitatively compare how the intraarterial
(IA) and intravenous (IV) administration of the chemotherapeutic agent BCNU
affects animal tumor and non-tumor tissue drug distribution and tumor
response (volume changes and animal survival times).  The results will be
compared to those predicted by theoretical drug modeling systems.  In
addition, systemic toxicity, relative to the route and dose of drug
administration will be monitored and compared.  The research will also
investigate the effects of steroids and perfluorocarbons when used in
combination with IA and IV chemotherapy.  The effects of each of these
combined with chemotherapy treatments on drug distribution in brain tumor
and non-tumor tissue and tumor response will be studied.  Diagnostic x-ray,
CT and NMR imaging will be employed to help evaluate the effects of
steroids on reducing edema associated with the tumor.  This research is of
particular importance since the incidence of human brain tumors is
significant and the results of conventional forms of therapy are poor.  The
work proposed in this application should provide important information that
is currently lacking and which should improve knowledge regarding the role
of Interventional Radiology in brain tumor therapy.  Results of the study
should help to develop new forms of therapy to improve the care and
management of the brain tumor patient.

## Key facts

- **NIH application ID:** 3174568
- **Project number:** 3R01CA036920-03S1
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **SAM.gov UEI:** FTMTDMBR29C7
- **Principal Investigator:** JAMES H ANDERSON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $28,150
- **Award type:** 3
- **Project period:** 1984-05-01 → 1990-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3174568

## Citation

> US National Institutes of Health, RePORTER application 3174568, DIAGNOSTIC RADIOLOGY-IMAGING--CHEMOTHERAPY-BRAIN TUMOR (3R01CA036920-03S1). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3174568. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*