# DIAGNOSTIC RADIOLOGY-IMAGING, CHEMOTHERAPY-BRAIN TUMOR

> **NIH NIH R01** · JOHNS HOPKINS UNIVERSITY · 1990 · $246,431

## Abstract

The long term objective of our animal research is to provide
important information necessary to improve the clinical application
of intraarterial chemotherapy for treating brain tumors.  More
specifically, we will continue our current studies aimed at
delineating the pharmacokinetic parameters associated with
intraarterial administration of chemotherapeutic agents.  Emphasis
will be placed on evaluating how the intraarterial advantage (Rd)
of drug delivery can be improved through (1) modifying the manner
in which BCNU is dissolved for infusion; (2) using steroids and non
steroid agents to reduce brain tumor edema and improve drug
delivery, and; (3) using a short half-life experimental
chemotherapeutic agent ideally suited for intraarterial delivery.
Attention will also be given to evaluating the pharmacokinetics of
IA and IV administered FUDR, which could theoretically have
positive practical application as a drug to be used in combination
with nitrosoureas in treating brain tumors.  Experimental results
will be compared to theoretical models of intraarterial drug
delivery.  In addition, physiological and morphologic parameters
such as blood flow, brain tissue edema, and brain tumor
ultrastructure will be measured and correlated with the
pharmacokinetic measured parameters of drug delivery.  This work
is particularly important since very few quantitative studies of
intraarterial chemotherapy for brain tumors have been reported.
The incidence of human brain tumors is significant and the results
of conventional forms of therapy are poor.  Although intraarterial
chemotherapy for brain tumors has provided some hope of improving
patient prognosis, information regarding the basic pharmacokinetics
of this approach is lacking.  Such basic information is essential
in order to optimize drug delivery parameters.  This information
is particularly important to the Interventional Radiology community
which is directly involved in intraarterial chemotherapy of brain
tumors.

## Key facts

- **NIH application ID:** 3174571
- **Project number:** 5R01CA036920-05
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **SAM.gov UEI:** FTMTDMBR29C7
- **Principal Investigator:** JAMES H ANDERSON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $246,431
- **Award type:** 5
- **Project period:** 1984-05-01 → 1991-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3174571

## Citation

> US National Institutes of Health, RePORTER application 3174571, DIAGNOSTIC RADIOLOGY-IMAGING, CHEMOTHERAPY-BRAIN TUMOR (5R01CA036920-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3174571. Licensed CC0.

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